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Nigella Sativa COVID-19 studies. Recent:
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Sep 27
Early, Late, PrEP, PEP Covid Analysis (Preprint) (meta analysis)
Nigella Sativa for COVID-19: real-time meta analysis of 10 studies
Details   • Statistically significant improvements are seen for mortality, hospitalization, recovery, cases, and viral clearance. 6 studies from 5 independent teams in 4 different countries show statistically significant improvements in isolation (..
Jul 11
In Vitro Sherwani et al., Processes, doi:10.3390/pr10071346 (In Vitro)
In Vitro
Pharmacological Profile of Nigella sativa Seeds in Combating COVID-19 through In-Vitro and Molecular Docking Studies
Details   In Vitro study of nigella sativa's effect on oxidative stress, hemolysis, proteolysis, and glycation, and In Silico study for SARS-CoV-2 antiviral potential, suggesting beneficial effects for COVID-19.
Jul 5
PrEPPEP Chandra et al., Phytotherapy Research, doi:10.1002/ptr.7531
cases, ↓49.0%, p=0.36
Efficacy of polyherbal formulations for prevention of COVID ‐19 infection in high‐risk subjects: A randomized open‐label controlled clinical trial
Details   RCT 251 high-risk individuals in India, mostly with direct contact with COVID-19 positive patients, testing polyherbal formulations Infuza, which includes nigella sativa, and Kulzam. Both formulations showed lower risk, without statisical..
Jun 3
Late Setayesh et al., Integrative Medicine Research, doi:10.1016/j.imr.2022.100869
death, ↑7.9%, p=1.00
Efficacy of a Persian herbal medicine compound on coronavirus disease 2019 (COVID-19): a randomized clinical trial
Details   Small RCT 41 patients treated with nigella sativa, glycyrrhiza glabra, punica granatum, and rheum palmatum, and 41 control patients, showing shorter hospitalization with treatment.
May 7
Early Bencheqroun et al., Pathogens, doi:10.3390/pathogens11050551
hosp., ↓69.3%, p=0.44
A Randomized, Double-Blind, Placebo-Controlled, Multicenter Study to Evaluate the Safety and Efficacy of ThymoQuinone Formula (TQF) for Treating Outpatient SARS-CoV-2
Details   52 patient RCT in the USA with nigella sativa component thymoquinone, showing improved recovery with treatment. There was a significantly faster decline in the total symptom burden, and a significant increase in CD8+ and helper CD4+ centr..
Apr 20
Dosing Thomas et al., Toxicology Reports, doi:10.1016/j.toxrep.2022.04.020 (Dosing)
dosing study
A phase I clinical trial to evaluate the safety of thymoquinone -rich black cumin oil (BlaQmax®) on healthy subjects: Randomized, double-blinded, placebo-controlled prospective study
Details   Phase 1 trial of high thymoquinone content (5%) black cumin oil finding treatment to be safe without any major side effects or adverse events. There was a significant reduction in total cholesterol, LDL, and triglycerides, and increased H..
Feb 28
PrEPPEP Shehab et al., Tropical Journal of Pharmaceutical Research, doi:10.4314/tjpr.v21i2.13
severe case, ↓0.2%, p=1.00
Immune-boosting effect of natural remedies and supplements on progress of, and recovery from COVID-19 infection
Details   Retrospective survey-based analysis of 349 COVID-19 patients, showing no significant difference with nigella sativa prophylaxis in unadjusted analysis. REC/UG/2020/03.
Jan 24
In Silico Khan et al., Brazilian Journal of Biology, doi:10.1590/1519-6984.25066
In Silico
Inhibitory effect of thymoquinone from Nigella sativa against SARS-CoV-2 main protease. An in-silico study
Details   In Silico analysis of thymoquinone from nigella sativa showing good binding affinity with SARS-CoV-2 Mpro.
Jan 1
In Vitro Esharkawy et al., Bioorganic Chemistry, doi:10.1016/j.bioorg.2021.105587 (In Vitro)
In Vitro
In vitro Potential Antiviral SARS-CoV-19- Activity of Natural Product Thymohydroquinone and Dithymoquinone from Nigela sativia
Details   In Vitro and In Silico study of nigella sativa components, showing anti-SARS-CoV-2 activity at non-cytotoxic nanomolar concentrations for thymohydroquinone with selectivity index 1.4.
Dec 22
In Silico Banerjee et al., Natural Product Research, doi:10.1080/14786419.2021.2018430
In Silico
Nigellidine (Nigella sativa, black-cumin seed) docking to SARS CoV-2 nsp3 and host inflammatory proteins may inhibit viral replication/transcription
Details   In Silico study showing nigella sativa docking to SARS CoV-2 Nsp3 and host inflammatory proteins, which may inhibit viral replication.
Oct 13
In Silico Rizvi et al., Processes, doi:10.3390/pr9101814
In Silico
Identifying the Most Potent Dual-Targeting Compound(s) against 3CLprotease and NSP15exonuclease of SARS-CoV-2 from Nigella sativa: Virtual Screening via Physicochemical Properties, Docking and Dynamic Simulation Analysis
Details   In Silico study predicting that nigella sativa component dithymoquinone has good affinity and stability against SARS-CoV-2 3CLpro and NSP15, suggesting potential benefits for COVID-19 treatment.
Oct 4
Late Karimi et al., Phytotherapy Research, doi:10.1002/ptr.7277
death, ↓50.8%, p=0.45
Efficacy of Persian medicine herbal formulations (capsules and decoction) compared to standard care in patients with COVID-19, a multicenter open-labeled, randomized, controlled clinical trial
Details   RCT 358 hospitalized patients in Iran, 184 receiving treatment with a combination of nigella sativa and several other herbal medicines, showing shorter hospitalization time and improved recovery with treatment. IR.TUMS.VCR.REC.1399.024.
Sep 8
In Silico Mir et al., Saudi Journal of Biological Sciences, doi:10.1016/j.sjbs.2021.09.002
In Silico
Identification of SARS-CoV-2 RNA-dependent RNA polymerase inhibitors from the major phytochemicals of Nigella sativa: An in silico approach
Details   In Silico study identifying phytochemicals from nigella sativa (𝛼-hederin, dithymoquinone, negillicine, and negillidine) as potential SARS-CoV-2 RNA-dependent RNA polymerase inhibitors.
Aug 15
Early Koshak et al., Complementary Therapies in Medicine, doi:10.1016/j.ctim.2021.102769
hosp., ↓74.7%, p=0.37
Nigella sativa for the treatment of COVID-19: An open-label randomized controlled clinical trial
Details   RCT 183 mild COVID-19 outpatients in Saudi Arabia, 91 treated with Nigella Sativa, showing lower hospitalization and faster recovery with treatment. 500mg Nigella Sativa oil (MARNYS Cuminmar) twice daily for 10 days. NCT04401202.
Jul 27
Review Al-Gabri et al., International Journal of Nanomedicine, doi: (Review)
Therapeutic Potential of Thymoquinone and Its Nanoformulations in Pulmonary Injury: A Comprehensive Review
Details   Review of thymoquinone (a component of nigella sativa) research, antioxidant, anti-inflammatory, and antineoplastic properties, application to lung conditions, and the potential advantages of nanoformulations on drug solubility, cellular ..
Jul 23
Review Ahmad et al., Vascular Pharmacology, doi:10.1016/j.vph.2021.106899 (Review)
The potential role of thymoquinone in preventing the cardiovascular complications of COVID-19
Details   Review of the potential role of thymoquinone (a component of nigella sativa) in minimizing cardiovascular complications of COVID-19.
Jul 23
Review Shad et al., Clinical and Experimental Pharmacology and Physiology, doi:10.1111/1440-1681.13553 (Review)
The role of thymoquinone, a major constituent of Nigella sativa, in the treatment of inflammatory and infectious diseases
Details   Review of the pharmacological properties of nigella sativa and thymoquinone and application for a variety of diseases, focusing on recent studies of the anti-inflammatory and antiviral properties that are promising for diseases including ..
Jul 12
In Silico Hardianto et al., Indonesian Journal of Chemistry, doi:10.22146/ijc.65951
In Silico
Exploring the Potency of Nigella sativa Seed in Inhibiting SARS-CoV-2 Main Protease Using Molecular Docking and Molecular Dynamics Simulations
Details   In Silico study showing nigella sativa metabolites binding to SARS-CoV-2 Mpro.
May 11
Early Aldwihi et al., International Journal of Environmental Research and Public Health, doi:10.3390/ijerph18105086
hosp., ↓24.0%, p=0.09
Patients’ Behavior Regarding Dietary or Herbal Supplements before and during COVID-19 in Saudi Arabia
Details   Retrospective survey-based analysis of 738 COVID-19 patients in Saudi Arabia, showing lower hospitalization with vitamin C, turmeric, zinc, and nigella sativa, and higher hospitalization with vitamin D. For vitamin D, most patients contin..
May 5
In Silico Maiti et al., Research Square, doi:10.21203/ (Preprint)
In Silico
Active-site Molecular docking of Nigellidine to nucleocapsid/Nsp2/Nsp3/MPro of COVID-19 and to human IL1R and TNFR1/2 may stop viral-growth/cytokine-flood, and the drug source Nigella sativa (black cumin) seeds show potent antioxidant role in experimental rats
Details   In Silico and animal study of nigella sativa and component nigellidine, showing nigellidine binding activity for several important SARS-CoV-2 proteins and for relevant host receptors; and that black cumin seed extract was antioxidative, h..
Mar 12
In Silico Duru et al., Bulletin of the National Research Centre, doi:10.1186/s42269-021-00517-x
In Silico
In silico identification of compounds from Nigella sativa seed oil as potential inhibitors of SARS-CoV-2 targets
Details   In Silico study of compounds from Nigella Sativa oil. Authors identify component phytochemicals with gas chromatography-mass spectrometry and analyze binding affinity with SARS-CoV-2 targets. Caryophyllene oxide, α-bergamotene, and β-bisa..
Mar 4
Early Fetian et al., Healthbook Times, doi:10.36000/hbT.2021.01.001 Response to Nigella sativa in Patients with Confirmed and Suspected COVID-19
Details   Retrospective 35 patients treated with Nigella Sativa showing good outcomes and relatively fast recovery. There was no control group.
Jan 31
PrEPPEP Al-Haidari et al., Pakistan Journal of Medical and Health Sciences, 15:1
symp. case, ↓62.2%, p<0.0001
Preventive Value of Black Seed in People at Risk of Infection with COVID-19
Details   Prophylaxis study with 376 mostly high-risk patients, 188 treated with nigella sativa, showing significantly lower cases with treatment. Black seeds 40mg/kg orally once daily.
Jan 31
Early Al-Haidari et al., Indian Journal of Forensic Medicine & Toxicology, 15:3 (date from earlier preprint)
death, ↓95.8%, p=0.001
Clinical Trial of Black Seeds Against COVID – 19 in Kirkuk City / Iraq
Details   Open-label RCT with 419 patients in Iraq, 160 treated with Nigella Sativa, showing lower mortality and severe cases with treatment. Black seeds 40mg/kg orally once daily for 14 days.
Nov 3
Early Ashraf et al., medRxiv, doi:10.1101/2020.10.30.20217364 (Preprint)
death, ↓81.9%, p=0.01
Honey and Nigella sativa against COVID-19 in Pakistan (HNS-COVID-PK): A multi-center placebo-controlled randomized clinical trial
Details   RCT with 157 patients treated with honey and nigella sativa, and 156 control patients, showing significantly faster recovery and viral clearance. Honey (1gm/kg/day) plus encapsulated nigella sativa seeds (80mg/kg/day) orally in 2-3 divide..
Oct 15
Early El Sayed et al., Am J Blood Res., doi: Promising preventive and therapeutic effects of TaibUVID nutritional supplements for COVID-19 pandemic: towards better public prophylaxis and treatment (A retrospective study)
Details   Small retrospective study of 20 patients in Egypt suggesting benefits of TaibUVID (nigella sativa, chamomile and honey) treatment.
Jul 10
Review Kulyar et al., Phytomedicine, doi:10.1016/j.phymed.2020.153277 (Review)
Potential influence of Nagella sativa (Black cumin) in reinforcing immune system: A hope to decelerate the COVID-19 pandemic
Details   Review of immune-regulating, anti-inflammatory, and antioxidant benefits of nigella sativa, and potential benefits for COVID-19.
Jun 26
Review Ahmad et al., Phytotherapy Research, doi:10.1002/ptr.6793 (Review) (Preprint)
Covid-19 and thymoquinone: Connecting the dots
Details   Review of the potential benefits of thymoquinone (a component of nigella sativa) for COVID-19, recommending clinical trials.
Apr 2
In Silico Bouchentouf et al., ChemRxiv, doi:10.26434/chemrxiv.12055716.v1 (Preprint)
In Silico
Identification of Compounds from Nigella Sativa as New Potential Inhibitors of 2019 Novel Coronasvirus (Covid-19): Molecular Docking Study
Details   In Silico study of compounds from nigella sativa identifying nigellidine and α-Hederin as potential compounds that inhibit SARS-CoV-2.
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