Antiandrogens
Aspirin
Bamlanivimab
Bromhexine
Budesonide
Casirivimab/i..
Colchicine
Conv. Plasma
Curcumin
Favipiravir
Fluvoxamine
Hydroxychloro..
Iota-carragee..
Ivermectin
Melatonin
Metformin
Molnupiravir
Nigella Sativa
Nitazoxanide
Paxlovid
Povidone-Iod..
Probiotics
Proxalutamide
Quercetin
Remdesivir
Sotrovimab
Vitamin A
Vitamin C
Vitamin D
Zinc

Other
Feedback
Home
Home   COVID-19 treatment studies for Nigella Sativa  COVID-19 treatment studies for Nigella Sativa  C19 studies: Nigella Sativa  Nigella Sativa   Select treatmentSelect treatmentTreatmentsTreatments
Antiandrogens (meta) Metformin (meta)
Aspirin (meta) Molnupiravir (meta)
Bamlanivimab (meta) Nigella Sativa (meta)
Bromhexine (meta) Nitazoxanide (meta)
Budesonide (meta) Paxlovid (meta)
Casirivimab/i.. (meta) Povidone-Iod.. (meta)
Colchicine (meta) Probiotics (meta)
Conv. Plasma (meta) Proxalutamide (meta)
Curcumin (meta) Quercetin (meta)
Favipiravir (meta) Remdesivir (meta)
Fluvoxamine (meta) Sotrovimab (meta)
Hydroxychloro.. (meta) Vitamin A (meta)
Iota-carragee.. (meta) Vitamin C (meta)
Ivermectin (meta) Vitamin D (meta)
Melatonin (meta) Zinc (meta)

Other Treatments Global Adoption
 
0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ Ashraf (RCT) 82% 0.18 [0.04-0.80] death 2/157 11/156 CT​1 Improvement, RR [CI] Treatment Control Al-Haidari (RCT) 96% 0.04 [0.00-0.70] death 0/160 14/259 Koshak (RCT) 75% 0.25 [0.03-2.22] hosp. 1/91 4/92 Tau​2 = 0.00; I​2 = 0.0% Early treatment 84% 0.16 [0.05-0.48] 3/408 29/507 84% improvement Al-Haidari 62% 0.38 [0.31-0.46] symp. case 68/188 180/188 Improvement, RR [CI] Treatment Control Tau​2 = 0.00; I​2 = 0.0% Prophylaxis 62% 0.38 [0.31-0.46] 68/188 180/188 62% improvement All studies 67% 0.33 [0.21-0.52] 71/596 209/695 67% improvement 4 nigella sativa COVID-19 studies c19ns.com Dec 7, 2021 1 CT: study uses combined treatmentTau​2 = 0.06; I​2 = 10.1%; Z = 4.72 Effect extraction pre-specified Favors nigella sativa Favors control
Database of all nigella sativa COVID-19 studies. Submit updates/corrections.
 
Search:  
Restrict:    All    Early    Prophylaxis
Oct 13
In Silico Rizvi et al., Processes, doi:10.3390/pr9101814 (Peer Reviewed) Identifying the Most Potent Dual-Targeting Compound(s) against 3CLprotease and NSP15exonuclease of SARS-CoV-2 from Nigella sativa: Virtual Screening via Physicochemical Properties, Docking and Dynamic Simulation Analysis
Details   In Silico study predicting that nigella sativa component dithymoquinone has good affinity and stability against SARS-CoV-2 3CLpro and NSP15, suggesting potential benefits for COVID-19 treatment.
Sep 8
In Silico Mir et al., Saudi Journal of Biological Sciences, doi:10.1016/j.sjbs.2021.09.002 (Peer Reviewed) Identification of SARS-CoV-2 RNA-dependent RNA polymerase inhibitors from the major phytochemicals of Nigella sativa: An in silico approach
Details   In Silico study identifying phytochemicals from nigella sativa (𝛼-hederin, dithymoquinone, negillicine, and negillidine) as potential SARS-CoV-2 RNA-dependent RNA polymerase inhibitors.
Aug 15
Early Koshak et al., Complementary Therapies in Medicine, doi:10.1016/j.ctim.2021.102769 (Peer Reviewed)
hosp., ↓74.7%, p=0.37
Nigella sativa for the treatment of COVID-19: An open-label randomized controlled clinical trial
Details   RCT 183 mild COVID-19 outpatients in Saudi Arabia, 91 treated with Nigella Sativa, showing lower hospitalization and faster recovery with treatment. NCT04401202. 500mg Nigella sativa oil (MARNYS Cuminmar) twice daily for 10 days.
Jul 27
Review Al-Gabri et al., International Journal of Nanomedicine, doi:https://doi.org/10.2147/IJN.S314321 (Review) (Peer Reviewed)
review
Therapeutic Potential of Thymoquinone and Its Nanoformulations in Pulmonary Injury: A Comprehensive Review
Details   Review of thymoquinone (a component of nigella sativa) research, antioxidant, anti-inflammatory, and antineoplastic properties, application to lung conditions, and the potential advantages of nanoformulations on drug solubility, cellular ..
Jul 23
Review Ahmad et al., Vascular Pharmacology, doi:10.1016/j.vph.2021.106899 (Review) (Peer Reviewed)
review
The potential role of thymoquinone in preventing the cardiovascular complications of COVID-19
Details   Review of the potential role of thymoquinone (a component of nigella sativa) in minimizing cardiovascular complications of COVID-19.
Jul 23
Review Shad et al., Clinical and Experimental Pharmacology and Physiology, doi:10.1111/1440-1681.13553 (Review) (Peer Reviewed)
review
The role of thymoquinone, a major constituent of Nigella sativa, in the treatment of inflammatory and infectious diseases
Details   Review of the pharmacological properties of nigella sativa and thymoquinone and application for a variety of diseases, focusing on recent studies of the anti-inflammatory and antiviral properties that are promising for diseases including ..
Jul 12
In Silico Hardianto et al., Indonesian Journal of Chemistry, doi:10.22146/ijc.65951 (Peer Reviewed) Exploring the Potency of Nigella sativa Seed in Inhibiting SARS-CoV-2 Main Protease Using Molecular Docking and Molecular Dynamics Simulations
Details   In Silico study showing nigella sativa metabolites binding to SARS-CoV-2 Mpro.
May 5
In Silico Maiti et al., Research Square, doi:10.21203/rs.3.rs-26464/v1 (Preprint) Active-site Molecular docking of Nigellidine to nucleocapsid/Nsp2/Nsp3/MPro of COVID-19 and to human IL1R and TNFR1/2 may stop viral-growth/cytokine-flood, and the drug source Nigella sativa (black cumin) seeds show potent antioxidant role in experimental rats
Details   In Silico and animal study of nigella sativa and component nigellidine, showing nigellidine binding activity for several important SARS-CoV-2 proteins and for relevant host receptors; and that black cumin seed extract was antioxidative, h..
Mar 12
In Silico Duru et al., Bulletin of the National Research Centre, doi:10.1186/s42269-021-00517-x (Peer Reviewed) In silico identification of compounds from Nigella sativa seed oil as potential inhibitors of SARS-CoV-2 targets
Details   In Silico study of compounds from Nigella Sativa oil. Authors identify component phytochemicals with gas chromatography-mass spectrometry and analyze binding affinity with SARS-CoV-2 targets. Caryophyllene oxide, α-bergamotene, and β-bisa..
Mar 4
Early Fetian et al., Healthbook Times, doi:10.36000/hbT.2021.01.001 (Peer Reviewed) Response to Nigella sativa in Patients with Confirmed and Suspected COVID-19
Details   Retrospective 35 patients treated with Nigella Sativa showing good outcomes and relatively fast recovery. There was no control group.
Jan 31
PrEPPEP Al-Haidari et al., Pakistan Journal of Medical and Health Sciences, 15:1 (Peer Reviewed)
symp. case, ↓62.2%, p<0.0001
Preventive Value of Black Seed in People at Risk of Infection with COVID-19
Details   Prophylaxis study with 376 mostly high-risk patients, 188 treated with nigella sativa, showing significantly lower cases with treatment. Black seeds 40mg/kg orally once daily.
Jan 31
Early Al-Haidari et al., Indian Journal of Forensic Medicine & Toxicology, 15:3 (preprint 1/2021) (Peer Reviewed)
death, ↓95.8%, p=0.001
Clinical Trial of Black Seeds Against COVID – 19 in Kirkuk City / Iraq
Details   Open-label RCT with 419 patients in Iraq, 160 treated with Nigella Sativa, showing lower mortality and severe cases with treatment. Black seeds 40mg/kg orally once daily for 14 days.
Nov 3
2020
Early Ashraf et al., medRxiv, doi:10.1101/2020.10.30.20217364 (Preprint)
death, ↓81.9%, p=0.01
Honey and Nigella sativa against COVID-19 in Pakistan (HNS-COVID-PK): A multi-center placebo-controlled randomized clinical trial
Details   RCT with 157 patients treated with honey and nigella sativa, and 156 control patients, showing significantly faster recovery and viral clearance. NCT04347382. Honey (1gm/kg/day) plus encapsulated Nigella sativa seeds (80mg/kg/day) orally..
Oct 15
2020
Early El Sayed et al., Am J Blood Res., doi: (Peer Reviewed) Promising preventive and therapeutic effects of TaibUVID nutritional supplements for COVID-19 pandemic: towards better public prophylaxis and treatment (A retrospective study)
Details   Small retrospective study of 20 patients in Egypt suggesting benefits of TaibUVID (nigella sativa, chamomile and honey) treatment.
Jul 10
2020
Review Kulyar et al., Phytomedicine, doi:10.1016/j.phymed.2020.153277 (Review) (Peer Reviewed)
review
Potential influence of Nagella sativa (Black cumin) in reinforcing immune system: A hope to decelerate the COVID-19 pandemic
Details   Review of immune-regulating, anti-inflammatory, and antioxidant benefits of nigella sativa, and potential benefits for COVID-19.
Jun 26
2020
Review Ahmad et al., Phytotherapy Research, doi:10.1002/ptr.6793 (Review) (Preprint)
review
Covid-19 and thymoquinone: Connecting the dots
Details   Review of the potential benefits of thymoquinone (a component of nigella sativa) for COVID-19, recommending clinical trials.
Apr 2
2020
In Silico Bouchentouf et al., ChemRxiv, doi:10.26434/chemrxiv.12055716.v1 (Preprint) Identification of Compounds from Nigella Sativa as New Potential Inhibitors of 2019 Novel Coronasvirus (Covid-19): Molecular Docking Study
Details   In silico study of compounds from nigella sativa identifying nigellidine and α-Hederin as potential compounds that inhibit SARS-CoV-2.
Please send us corrections, updates, or comments. Vaccines and treatments are both extremely valuable and complementary. All practical, effective, and safe means should be used. Elimination of COVID-19 is a race against viral evolution. No treatment, vaccine, or intervention is 100% available and effective for all current and future variants. Denying the efficacy of any method increases the risk of COVID-19 becoming endemic; and increases mortality, morbidity, and collateral damage. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. Treatment protocols for physicians are available from the FLCCC.
  or use drag and drop   
Thanks for your feedback! Please search before submitting papers and note that studies are listed under the date they were first available, which may be the date of an earlier preprint.
Submit