Conv. Plasma
Nigella Sativa
Vitamin A
Vitamin C
Vitamin D

Home   COVID-19 treatment studies for Nigella Sativa  COVID-19 treatment studies for Nigella Sativa  C19 studies: Nigella Sativa  Nigella Sativa   Select treatmentSelect treatmentTreatmentsTreatments
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Other Adoption (RCT)82%0.18 [0.04-0.80]death2/15711/156CT​1Improvement, RR [CI]TreatmentControlAl-Haidari (RCT)96%0.04 [0.00-0.70]death0/16014/259Koshak (RCT)75%0.25 [0.03-2.22]hosp.1/914/92Tau​2 = 0.00; I​2 = 0.0%Early treatment84%0.16 [0.05-0.48]3/40829/50784% improvementAl-Haidari62%0.38 [0.31-0.46]symp. case68/188180/188Improvement, RR [CI]TreatmentControlTau​2 = 0.00; I​2 = 0.0%PrEP62%0.38 [0.31-0.46]68/188180/18862% improvementAll studies67%0.33 [0.21-0.52]71/596209/69567% improvement4 nigella sativa COVID-19 Oct 27, 20211 CT: study uses combined treatmentTau​2 = 0.06; I​2 = 10.1%; Z = 4.72Effect extraction pre-specifiedFavors nigella sativaFavors control
Database of all nigella sativa COVID-19 studies. Submit updates/corrections.
Sep 8
In Silico Mir et al., Saudi Journal of Biological Sciences, doi:10.1016/j.sjbs.2021.09.002 (Peer Reviewed) Identification of SARS-CoV-2 RNA-dependent RNA polymerase inhibitors from the major phytochemicals of Nigella sativa: An in silico approach
Details   In Silico study identifying phytochemicals from nigella sativa (𝛼-hederin, dithymoquinone, negillicine, and negillidine) as potential SARS-CoV-2 RNA-dependent RNA polymerase inhibitors.
Aug 15
Early Koshak et al., Complementary Therapies in Medicine, doi:10.1016/j.ctim.2021.102769 (Peer Reviewed) hosp., ↓74.7%, p=0.37 Nigella sativa for the treatment of COVID-19: An open-label randomized controlled clinical trial
Details   RCT 183 mild COVID-19 outpatients in Saudi Arabia, 91 treated with Nigella Sativa, showing lower hospitalization and faster recovery with treatment. NCT04401202. 500mg Nigella sativa oil (MARNYS Cuminmar) twice daily for 10 days.
Jul 27
Review Al-Gabri et al., International Journal of Nanomedicine, doi: (Review) (Peer Reviewed) review Therapeutic Potential of Thymoquinone and Its Nanoformulations in Pulmonary Injury: A Comprehensive Review
Details   Review of thymoquinone (a component of nigella sativa) research, antioxidant, anti-inflammatory, and antineoplastic properties, application to lung conditions, and the potential advantages of nanoformulations on drug solubility, cellular ..
Jul 23
Review Ahmad et al., Vascular Pharmacology, doi:10.1016/j.vph.2021.106899 (Review) (Peer Reviewed) review The potential role of thymoquinone in preventing the cardiovascular complications of COVID-19
Details   Review of the potential role of thymoquinone (a component of nigella sativa) in minimizing cardiovascular complications of COVID-19.
Jul 23
Review Shad et al., Clinical and Experimental Pharmacology and Physiology, doi:10.1111/1440-1681.13553 (Review) (Peer Reviewed) review The role of thymoquinone, a major constituent of Nigella sativa, in the treatment of inflammatory and infectious diseases
Details   Review of the pharmacological properties of nigella sativa and thymoquinone and application for a variety of diseases, focusing on recent studies of the anti-inflammatory and antiviral properties that are promising for diseases including ..
Jul 12
In Silico Hardianto et al., Indonesian Journal of Chemistry, doi:10.22146/ijc.65951 (Peer Reviewed) Exploring the Potency of Nigella sativa Seed in Inhibiting SARS-CoV-2 Main Protease Using Molecular Docking and Molecular Dynamics Simulations
Details   In Silico study showing nigella sativa metabolites binding to SARS-CoV-2 Mpro.
May 5
In Silico Maiti et al., Research Square, doi:10.21203/ (Preprint) Active-site Molecular docking of Nigellidine to nucleocapsid/Nsp2/Nsp3/MPro of COVID-19 and to human IL1R and TNFR1/2 may stop viral-growth/cytokine-flood, and the drug source Nigella sativa (black cumin) seeds show potent antioxidant role in experimental rats
Details   In Silico and animal study of nigella sativa and component nigellidine, showing nigellidine binding activity for several important SARS-CoV-2 proteins and for relevant host receptors; and that black cumin seed extract was antioxidative, h..
Mar 12
In Silico Duru et al., Bulletin of the National Research Centre, doi:10.1186/s42269-021-00517-x (Peer Reviewed) In silico identification of compounds from Nigella sativa seed oil as potential inhibitors of SARS-CoV-2 targets
Details   In Silico study of compounds from Nigella Sativa oil. Authors identify component phytochemicals with gas chromatography-mass spectrometry and analyze binding affinity with SARS-CoV-2 targets. Caryophyllene oxide, α-bergamotene, and β-bisa..
Mar 4
Early Fetian et al., Healthbook Times, doi:10.36000/hbT.2021.01.001 (Peer Reviewed) Response to Nigella sativa in Patients with Confirmed and Suspected COVID-19
Details   Retrospective 35 patients treated with Nigella Sativa showing good outcomes and relatively fast recovery. There was no control group.
Jan 31
PrEP Al-Haidari et al., Pakistan Journal of Medical and Health Sciences, 15:1 (Peer Reviewed) symp. case, ↓62.2%, p<0.0001 Preventive Value of Black Seed in People at Risk of Infection with COVID-19
Details   Prophylaxis study with 376 mostly high-risk patients, 188 treated with nigella sativa, showing significantly lower cases with treatment. Black seeds 40mg/kg orally once daily.
Jan 31
Early Al-Haidari et al., Indian Journal of Forensic Medicine & Toxicology, 15:3 (preprint 1/2021) (Peer Reviewed) death, ↓95.8%, p=0.001 Clinical Trial of Black Seeds Against COVID – 19 in Kirkuk City / Iraq
Details   Open-label RCT with 419 patients in Iraq, 160 treated with Nigella Sativa, showing lower mortality and severe cases with treatment. Black seeds 40mg/kg orally once daily for 14 days.
Nov 3
Early Ashraf et al., medRxiv, doi:10.1101/2020.10.30.20217364 (Preprint) death, ↓81.9%, p=0.01 Honey and Nigella sativa against COVID-19 in Pakistan (HNS-COVID-PK): A multi-center placebo-controlled randomized clinical trial
Details   RCT with 157 patients treated with honey and nigella sativa, and 156 control patients, showing significantly faster recovery and viral clearance. NCT04347382. Honey (1gm/kg/day) plus encapsulated Nigella sativa seeds (80mg/kg/day) orally..
Oct 15
Early El Sayed et al., Am J Blood Res., doi: (Peer Reviewed) Promising preventive and therapeutic effects of TaibUVID nutritional supplements for COVID-19 pandemic: towards better public prophylaxis and treatment (A retrospective study)
Details   Small retrospective study of 20 patients in Egypt suggesting benefits of TaibUVID (nigella sativa, chamomile and honey) treatment.
Jul 10
Review Kulyar et al., Phytomedicine, doi:10.1016/j.phymed.2020.153277 (Review) (Peer Reviewed) review Potential influence of Nagella sativa (Black cumin) in reinforcing immune system: A hope to decelerate the COVID-19 pandemic
Details   Review of immune-regulating, anti-inflammatory, and antioxidant benefits of nigella sativa, and potential benefits for COVID-19.
Jun 26
Review Ahmad et al., Phytotherapy Research, doi:10.1002/ptr.6793 (Review) (Preprint) review Covid-19 and thymoquinone: Connecting the dots
Details   Review of the potential benefits of thymoquinone (a component of nigella sativa) for COVID-19, recommending clinical trials.
Apr 2
In Silico Bouchentouf et al., ChemRxiv, doi:10.26434/chemrxiv.12055716.v1 (Preprint) Identification of Compounds from Nigella Sativa as New Potential Inhibitors of 2019 Novel Coronasvirus (Covid-19): Molecular Docking Study
Details   In silico study of compounds from nigella sativa identifying nigellidine and α-Hederin as potential compounds that inhibit SARS-CoV-2.
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Thanks for your feedback! Please search before submitting papers and note that studies are listed under the date they were first available, which may be the date of an earlier preprint.