Ashraf, 313 patient nigella sativa early treatment RCT: 82% lower mortality [p=0.01], 84% improved recovery [p<0.0001], and 82% improved viral clearance [p<0.0001] https://c19p.org/ashraf2
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Honey and Nigella sativa against COVID-19 in Pakistan (HNS-COVID-PK): A multi-center placebo-controlled randomized clinical trial
et al., medRxiv, doi:10.1101/2020.10.30.20217364 (Preprint)
RCT with 157 patients treated with honey and nigella sativa, and 156 control patients, showing significantly faster recovery and viral clearance. NCT04347382.Honey (1gm/kg/day) plus encapsulated Nigella sativa seeds (80mg/kg/day) orally in 2-3 divided doses daily for up to 13 days.
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risk of death, 81.9% lower, RR 0.18, p = 0.01, treatment 2 of 157 (1.3%), control 11 of 156 (7.1%), NNT 17, all cases.
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risk of death, 67.1% lower, RR 0.33, p = 0.49, treatment 0 of 107 (0.0%), control 1 of 103 (1.0%), NNT 103, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm), moderate cases.
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risk of death, 78.8% lower, RR 0.21, p = 0.03, treatment 2 of 50 (4.0%), control 10 of 53 (18.9%), NNT 6.7, severe cases.
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risk of no recovery, 83.6% lower, HR 0.16, p < 0.001, treatment 107, control 103, moderate cases.
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risk of no recovery, 75.2% lower, HR 0.25, p < 0.001, treatment 50, control 53, severe cases.
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risk of no viral clearance, 81.9% lower, HR 0.18, p < 0.001, treatment 107, control 103, moderate cases.
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risk of no viral clearance, 76.9% lower, HR 0.23, p < 0.001, treatment 50, control 53, severe cases.
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| Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates |
Ashraf et al., 11/3/2020, Randomized Controlled Trial, Pakistan, South Asia, preprint, 48 authors, this trial uses multiple treatments in the treatment arm (combined with honey) - results of individual treatments may vary, trial NCT04347382.
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