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Nigella Sativa study #3   All Outcomes
0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ Mortality 82% Imp. Relative Risk, 95% CI Mortality (b) 67% Mortality (c) 79% Recovery 84% Recovery (b) 75% Virological cure 82% Virological cure (b) 77% Ashraf: Honey and Nigella sativa against COVID-19 in Pakistan (H.. Favors nigella sativa Favors control
11/3 Early treatment study
Ashraf et al., medRxiv, doi:10.1101/2020.10.30.20217364 (Preprint)
Honey and Nigella sativa against COVID-19 in Pakistan (HNS-COVID-PK): A multi-center placebo-controlled randomized clinical trial
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RCT with 157 patients treated with honey and nigella sativa, and 156 control patients, showing significantly faster recovery and viral clearance. NCT04347382.
Honey (1gm/kg/day) plus encapsulated Nigella sativa seeds (80mg/kg/day) orally in 2-3 divided doses daily for up to 13 days.
risk of death, 81.9% lower, RR 0.18, p = 0.01, treatment 2 of 157 (1.3%), control 11 of 156 (7.1%), all cases.
risk of death, 67.1% lower, RR 0.33, p = 0.49, treatment 0 of 107 (0.0%), control 1 of 103 (1.0%), relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm), moderate cases.
risk of death, 78.8% lower, RR 0.21, p = 0.03, treatment 2 of 50 (4.0%), control 10 of 53 (18.9%), severe cases.
risk of no recovery, 83.6% lower, RR 0.16, p < 0.001, treatment 107, control 103, moderate cases.
risk of no recovery, 75.2% lower, RR 0.25, p < 0.001, treatment 50, control 53, severe cases.
risk of no virological cure, 81.9% lower, RR 0.18, p < 0.001, treatment 107, control 103, moderate cases.
risk of no virological cure, 76.9% lower, RR 0.23, p < 0.001, treatment 50, control 53, severe cases.
Ashraf et al., 11/3/2020, Randomized Controlled Trial, Pakistan, South Asia, preprint, 48 authors, this trial uses multiple treatments in the treatment arm (combined with honey) - results of individual treatments may vary.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. For an individual study the most serious outcome may have a smaller number of events and lower statistical significance, however this provides the strongest evidence for the most serious outcomes when combining the results of many trials.
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