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0 0.5 1 1.5 2+ Hospitalization 69% Improvement Relative Risk Time to sustained clinical.. 9% Time to sustained clini.. (b) 35% Viral clearance 43% c19ns.com Bencheqroun et al. Nigella Sativa for COVID-19 RCT EARLY Favors nigella sativa Favors control
Bencheqroun, 52 patient nigella sativa early treatment RCT: 9% faster improvement [p=0.78] and 43% improved viral clearance [p=0.31] https://c19p.org/bencheqroun
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A Randomized, Double-Blind, Placebo-Controlled, Multicenter Study to Evaluate the Safety and Efficacy of ThymoQuinone Formula (TQF) for Treating Outpatient SARS-CoV-2
Bencheqroun et al., Pathogens, doi:10.3390/pathogens11050551
7 May 2022    Source   PDF   Share   Tweet
52 patient RCT in the USA with nigella sativa component thymoquinone, showing improved recovery with treatment. There was a significantly faster decline in the total symptom burden, and a significant increase in CD8+ and helper CD4+ central memory T lymphocytes. The treatment group contained 5 more vaccinated patients and 7 more overweight patients. Authors also present in vitro results showing an inhibitory effect with five SARS-CoV-2 variants including omicron.
risk of hospitalization, 69.3% lower, RR 0.31, p = 0.44, treatment 0 of 29 (0.0%), control 1 of 23 (4.3%), NNT 23, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm).
time to sustained clinical response, 9.1% lower, HR 0.91, p = 0.78, treatment 28, control 23, inverted to make RR<1 favor treatment, Kaplan–Meier.
time to sustained clinical response, 35.5% lower, HR 0.65, p = 0.25, treatment 28, control 23, inverted to make RR<1 favor treatment, Kaplan–Meier, high-risk patients.
risk of no viral clearance, 43.5% lower, RR 0.57, p = 0.31, treatment 5 of 21 (23.8%), control 8 of 19 (42.1%), NNT 5.5, day 14.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Bencheqroun et al., 7 May 2022, Double Blind Randomized Controlled Trial, placebo-controlled, USA, peer-reviewed, mean age 45.0, 25 authors, study period 27 May, 2021 - 27 September, 2021.
Contact: h.bencheqroun@respireresearch.com (corresponding author), r.fortunet@respireresearch.com, yasirahmed.med@gmail.com, cbarrera@ummc.care, mariya@ummc.care, mehmet.kocaktas@gmail.com, evilla@moraleshealthcare.com, emmanueli@tranquilconsulting.com, deborahb@tranquilconsulting.com, chineduo@tranquilconsulting.com, olaa@tranquilconsulting.com, karim@tranquilconsulting.com, spondell@ibtsolutions.us, amr.mohamed@uhhospitals.org, yimohamed@mdanderson.org, bgok@mdanderson.org, mkaseb1@gmail.com, okasseb@hotmail.com, mgocio@novatekpharmaceuticals.com, pt22064@comcast.net, danli@mdanderson.org, qma@mdanderson.org, jimmy_lu@codexbio.com, abdu94@yahoo.com, akaseb@mdanderson.org.
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