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0 0.5 1 1.5 2+ Case 49% Improvement Relative Risk Case (b) 87% Case (c) 74% c19ns.com Chandra et al. CTRI/2020/08/027222 Nigella Sativa RCT Prophylaxis Favors nigella sativa Favors control
Chandra, 105 patient nigella sativa prophylaxis RCT: 49% fewer cases [p=0.36] https://c19p.org/chandra
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Efficacy of polyherbal formulations for prevention of COVID ‐19 infection in high‐risk subjects: A randomized open‐label controlled clinical trial
Chandra et al., Phytotherapy Research, doi:10.1002/ptr.7531, CTRI/2020/08/027222
5 Jul 2022    Source   PDF   Share   Tweet
RCT 251 high-risk individuals in India, mostly with direct contact with COVID-19 positive patients, testing polyherbal formulations Infuza, which includes nigella sativa, and Kulzam. Both formulations showed lower risk, without statisical significance, while the best results were from the combination of both.
risk of case, 49.0% lower, RR 0.51, p = 0.36, treatment 4 of 52 (7.7%), control 8 of 53 (15.1%), NNT 14, Infuza.
risk of case, 87.0% lower, RR 0.13, p = 0.03, treatment 1 of 51 (2.0%), control 8 of 53 (15.1%), NNT 7.6, Infuza and Kulzam.
risk of case, 74.0% lower, RR 0.26, p = 0.09, treatment 2 of 51 (3.9%), control 8 of 53 (15.1%), NNT 9.0, Kulzam.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Chandra et al., 5 Jul 2022, Randomized Controlled Trial, India, peer-reviewed, 12 authors, study period 18 September, 2020 - 21 May, 2021, this trial uses multiple treatments in the treatment arm (combined with Infuza polyherbal formulation) - results of individual treatments may vary, trial CTRI/2020/08/027222.
Contact: mridududeja@yahoo.com.
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