Potential influence of Nagella sativa (Black cumin) in reinforcing immune system: A hope to decelerate the COVID-19 pandemic
Muhammad Fakhar-E-Alam Kulyar, Rongrong Li, Khalid Mehmood, Muhammad Waqas, Kun Li, Jiakui Li
Phytomedicine, doi:10.1016/j.phymed.2020.153277
Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre -including this research content -immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
Author contributions All data were generated in-house, and no paper mill was used. All authors agree to be accountable for all aspects of work ensuring integrity and accuracy.
CRediT authorship contribution statement Muhammad Fakhar-e-Alam Kulyar: Conceptualization, Writing -original draft. Rongrong Li: Writing -review & editing. Khalid Mehmood: Software, Visualization. Muhammad Waqas: Writingreview & editing. Kun Li: Formal analysis. Jiakui Li: Validation, Supervision.
Declaration of Competing Interest The authors declare no competing financial interests.
References
Abidi, Robbe, Kourda, Khamsa, Ben et al., Nigella sativa, a traditional Tunisian herbal medicine, attenuates bleomycin-induced pulmonary fibrosis in a rat model, Biomed. Pharmacother
Ahmad, Husain, Mujeeb, Khan, Najmi et al., A review on therapeutic potential of Nigella sativa: a miracle herb, Asian Pac. J. Trop. Biomed
Ahmad, Mishra, Vyawahare, Kumar, Rehman et al., Thymoquinone (2-Isoprpyl-5-methyl-1, 4-benzoquinone) as a chemopreventive/anticancer agent: chemistry and biological effects, Saudi Pharm. J
Akhtar, Shaukat, Zahoor, Chen, Wang et al., Anti-inflammatory effects of Hederacoside-C on Staphylococcus aureus induced inflammation via TLRs and their downstream signal pathway in vivo and in vitro, Microb. Pathog
Al Mutair, Ambani, Narrative review of Middle East respiratory syndrome coronavirus (MERS-CoV) infection: updates and implications for practice, J. Int. Med. Res
Al-Hazmi, Challenges presented by MERS corona virus, and SARS corona virus to global health, Saudi J. Biol. Sci
Al-Jawad, Al-Razzuqi, Hashim, Ismael, Broncho-relaxant activity of Nigella sativa versus anthemisnobilis in chronic bronchial asthma; a comparative study of efficacy, IOSR J Pharmac
Al-Sheddi, Farshori, Al-Oqail, Musarrat, Al-Khedhairy et al., Cytotoxicity of Nigella sativa seed oil and extract against human lung cancer cell line, Asian Pac J Cancer Prev
Ali, Amin, Ahmad, Ali, Ali et al., Bioavailability enhancement studies of amoxicillin with Nigella, Indian J. Med. Res
Amin, Hosseinzadeh, Black cumin (Nigella sativa) and its active constituent, thymoquinone: an overview on the analgesic and anti-inflammatory effects, Planta Med
Ammar, Gameil, Shawky, Nader, Comparative evaluation of anti-inflammatory properties of thymoquinone and curcumin using an asthmatic murine model, Int. Immunopharmacol
Angulo, Lecuona, Sznajder, Role of MicroRNAs in lung disease, Arch. Bronconeumol. (English Ed
Aziz, Son, Cho, Thymoquinone suppresses IRF-3-mediated expression of type I interferons via suppression of TBK1, Int. J. Mol. Sci
Bai, Cao, Zhang, Xiang, Ren et al., Direct screening of G-quadruplex ligands from Kalopanax septemlobus (Thunb.) Koidz extract by high performance liquid chromatography, J. Chromatogr. A
Bayir, Albayrak, Can, Karagoz, Cakir et al., Nigella sativa as a potential therapy for the treatment of lung injury caused by cecal ligation and puncture-induced sepsis model in rats, Cell Mol Biol
Bedford, Enria, Giesecke, Heymann, Ihekweazu et al., COVID-19: towards controlling of a pandemic, Lancet
Boskabady, Javan, Sajady, Rakhshandeh, The possible prophylactic effect of Nigella sativa seed extract in asthmatic patients, Fundam. Clin. Pharmacol
Boskabady, Keyhanmanesh, Saadatloo, Relaxant effects of different fractions from Nigella sativa L. on guinea pig tracheal chains and its possible mechanism
Bouchentouf, Missoum, Collison, Herbert, Siegle et al., Identification of Compounds from Nigella Sativa as New Potential Inhibitors of 2019 Novel Coronasvirus (Covid-19, BMC Pulm. Med
Cui, Li, Shi, Origin and evolution of pathogenic coronaviruses, Nat. Rev. Microbiol
Da, Hyun, Jeong, Kim, Lee, Antiinflammatory activity of $α$-hederin methyl ester from the alkaline hydrolysate of the butanol fraction of Kalopanax pictus bark extract, Biol. Pharm. Bull
Dajani, Shahwan, Dajani, Overview of the Human Investigations of Nigella sativa (Black Seeds): a Complementary Drug with Historical and Clinical Significance
Danzi, Loffi, Galeazzi, Gherbesi, Acute pulmonary embolism and COVID-19 pneumonia: a random association?, Eur. Heart J
Darakhshan, Pour, Colagar, Sisakhtnezhad, Thymoquinone and its therapeutic potentials, Pharmacol. Res
Dragan, Hargreaves, Makeyeva, Privalov, Mechanisms of activation of interferon regulator factor 3: the role of C-terminal domain phosphorylation in IRF-3 dimerization and DNA binding, Nucleic Acids Res
Dubey, Singh, Mishra, Kant, Solanki, Nigella (Nigella sativa L.): a high value seed spice with immense medicinal potential, Indian J. Agric. Sci
Ebrahimi, Fallahi, Khamaneh, Ebrahimi Saadatlou, Saadat et al., Effect of $α$-Hederin on IL-2 and IL-17 mRNA and miRNA-133a Levels in lungs of ovalbumin-sensitized male rats, Drug Dev. Res
El Gazzar, El Mezayen, Marecki, Nicolls, Canastar et al., Anti-inflammatory effect of thymoquinone in a mouse model of allergic lung inflammation, Int. Immunopharmacol
El-Khouly, El-Bakly, Awad, El-Mesallamy, El-Demerdash, Thymoquinone blocks lung injury and fibrosis by attenuating bleomycin-induced oxidative stress and activation of nuclear factor Kappa-B in rats, Toxicology
El-Tahir, Bakeet, The black seed Nigella sativa Linnaeus-A mine for multi cures: a plea for urgent clinical evaluation of its volatile oil, J. Taibah Univ. Med. Sci
Enomoto, Asano, Iwahori, Narui, Okada et al., Hematological studies on black cumin oil from the seeds of Nigella sativa L, Biol. Pharm. Bull
Fallah Huseini, Amini, Mohtashami, Ghamarchehre, Sadeqhi et al., Blood pressure lowering effect of Nigella sativa L. seed oil in healthy volunteers: a randomized, double-blind, placebocontrolled clinical trial, Phyther. Res
Fallahi, Keyhanmanesh, Khamaneh, Saadatlou, Saadat et al., Effect of Alpha-Hederin, the active constituent of Nigella sativa, on miRNA-126, IL-13 mRNA levels and inflammation of lungs in ovalbuminsensitized male rats, Avicenna J. phytomedicine
Forouzanfar, Bazzaz, Hosseinzadeh, Black cumin (Nigella sativa) and its constituent (thymoquinone): a review on antimicrobial effects, Iran. J. Basic Med. Sci
Gali-Muhtasib, El-Najjar, Schneider-Stock, The medicinal potential of black seed (Nigella sativa) and its components, Adv. Phytomedicine
Ghahramanloo, Kamalidehghan, Javar, Widodo, Majidzadeh et al., Comparative analysis of essential oil composition of iranian and indian nigella sativa L. Extracted using supercritical fluid extraction and solvent extraction, Drug Des. Devel. Ther
Gholamnezhad, Keyhanmanesh, Boskabady, Anti-inflammatory, antioxidant, and immunomodulatory aspects of Nigella sativa for its preventive and bronchodilatory effects on obstructive respiratory diseases: a review of basic and clinical evidence, J. Funct. Foods
Goyal, Prajapati, Gore, Patil, Mahajan et al., Therapeutic potential and pharmaceutical development of thymoquinone: a multitargeted molecule of natural origin, Front. Pharmacol
Greene, Gaughan, microRNAs in asthma: potential therapeutic targets, Curr. Opin. Pulm. Med
Grünig, Corry, Reibman, Wills-Karp, Interleukin 13 and the evolution of asthma therapy, Am. J. Clin. Exp. Immunol
Gu, Korteweg, Pathology and pathogenesis of severe acute respiratory syndrome, Am. J. Pathol
Hossein, Nasim, Sediqa, The protective effect of nigella sativa on lung injury of sulfur mustard-exposed guinea pigs, Exp. Lung Res
Hossen, Yang, Kim, Aravinthan, Kim et al., Thymoquinone: an IRAK1 inhibitor with in vivo and in vitro anti-inflammatory activities, Sci. Rep
Hui, Azhar, Madani, Ntoumi, Kock et al., The continuing 2019-nCoV epidemic threat of novel coronaviruses to global health The latest 2019 novel coronavirus outbreak in Wuhan, China, Int. J. Infect. Dis
Ijaz, Tulain, Qureshi, Danish, Musayab et al., Nigella sativa (Prophetic Medicine): a Review, Pak. J. Pharm. Sci
Ikhsan, Hiedayati, Maeyama, Nurwidya, Nigella sativa as an antiinflammatory agent in asthma, BMC Res. Notes
Islam, Khan, Mishra, An updated literature-based review: phytochemistry, pharmacology and therapeutic promises of Nigella sativa L, Orient. Pharm. Exp. Med
Keyhanmanesh, Nazemiyeh, Mazouchian, Asl, Shoar et al., Nigella sativa pretreatment in guinea pigs exposed to cigarette smoke modulates in vitro tracheal responsiveness, Iran. Red Crescent Med. J
Khader, Eckl, Thymoquinone: an emerging natural drug with a wide range of medical applications, Iran. J. Basic Med. Sci
Khan, Afzal, Chemical composition of Nigella sativa Linn: part 2 recent advances, Inflammopharmacology
Kokoska, Havlik, Valterova, Sovova, Sajfrtova et al., Comparison of chemical composition and antibacterial activity of Nigella sativa seed essential oils obtained by different extraction methods, J. Food Prot
Kooti, Hasanzadeh-Noohi, Sharafi-Ahvazi, Asadi-Samani, Ashtary-Larky, Phytochemistry, pharmacology, and therapeutic uses of black seed (Nigella sativa), Chin. J. Nat. Med
Li, Geng, Peng, Meng, Lu, Molecular immune pathogenesis and diagnosis of COVID-19, J. Pharm. Anal
Li, Wong, Li, Kuhn, Huang et al., Animal origins of the severe acute respiratory syndrome coronavirus: insight from ACE2-Sprotein interactions, J. Virol
Liu, Zhang, Jieying, Yang, Zhang et al., The potential role of IL-6 in monitoring coronavirus disease
Majdalawieh, Fayyad, Immunomodulatory and anti-inflammatory action of Nigella sativa and thymoquinone: a comprehensive review, Int. Immunopharmacol
Majeed, Muhammad, Ahmad, Hayat, Inayat et al., Nigella sativa L.: uses in traditional and contemporary medicines-An overview, Acta Ecol. Sin
Mansour, Nagi, El-Khatib, Al-Bekairi, Effects of thymoquinone on antioxidant enzyme activities, lipid peroxidation and DTdiaphorase in different tissues of mice: a possible mechanism of action, Cell Biochem. Funct
Mohebbati, Abbasnezhad, Effects of Nigella sativa on endothelial dysfunction in diabetes mellitus; A review, J. Ethnopharmacol
Mubarak, Alturaiki, Hemida, Middle east respiratory syndrome coronavirus (MERS-CoV): infection, immunological response, and vaccine development, J. Immunol. Res
Muhialdin, Alhelli, Hussin, The Effects of Different Extraction Methods on Antioxidant Properties, Chemical Composition, and Thermal Behavior of, Carcinogenesis
Oskouei, Akaberi, Hosseinzadeh, A glance at black cumin (Nigella sativa) and its active constituent, thymoquinone, in ischemia: a review, Iran. J. Basic Med. Sci
Oysu, Tosun, Yilmaz, Sahin-Yilmaz, Korkmaz et al., Topical Nigella Sativa for nasal symptoms in elderly, Auris Nasus Larynx
Pourgholamhossein, Sharififar, Rasooli, Pourgholi, Nakhaeipour et al., Thymoquinone effectively alleviates lung fibrosis induced by paraquat herbicide through down-regulation of pro-fibrotic genes and inhibition of oxidative stress, Environ. Toxicol. Pharmacol
Randhawa, Black seed, Nigella sativa, deserves more attention, J Ayub Med Coll Abbottabad
Rismanbaf, Potential Treatments for COVID-19; a Narrative Literature Review, Arch. Acad. Emerg. Med
Rooney, Ryan, Effects of alpha-hederin and thymoquinone, constituents of Nigella sativa, on human cancer cell lines, Anticancer Res
Rothan, Byrareddy, The epidemiology and pathogenesis of coronavirus disease (COVID-19) outbreak, J. Autoimmun
Saadat, Mohammadi, Fallahi, Aslani, The protective effect of $α $-hederin, the active constituent of Nigella sativa, on tracheal responsiveness and lung inflammation in ovalbumin-sensitized guinea pigs, J. Physiol. Sci
Salem, Bamosa, Qutub, Gupta, Badar et al., Effect of Nigella sativa supplementation on lung function and inflammatory mediators in partly controlled asthma: a randomized controlled trial, Ann. Saudi Med
Sardar, Satish, Birla, Gupta, coronavirus family genomes reveals unique features potentially consequential to host-virus interaction and pathogenesis
Shaterzadeh-Yazdi, Noorbakhsh, Samarghandian, Farkhondeh, An overview on renoprotective effects of Thymoquinone, Kidney Dis
Shrestha, Theerathavaj, Thaweboon, Thaweboon, In vitro antimicrobial effects of grape seed extract on peri-implantitis microflora in craniofacial implants, Asian Pac. J. Trop. Biomed
Srinivasan, Cumin (Cuminum cyminum) and black cumin (Nigella sativa) seeds: traditional uses, chemical constituents, and nutraceutical effects, Food Qual. Saf
Tang, He, Liu, Fang, Wu et al., AI-aided design of novel targeted covalent inhibitors against SARS-CoV-2
Tavakkoli, Mahdian, Razavi, Hosseinzadeh, Review on clinical trials of black seed (Nigella sativa) and its active constituent, thymoquinone, J. pharmacopuncture
Tembhurne, Feroz, More, Sakarkar, A review on therapeutic potential of Nigella sativa (kalonji) seeds, J Med Plants Res
Timen, Isken, Willemse, Van Den, Berkmortel et al., Retrospective evaluation of control measures for contacts of patient with Marburg hemorrhagic fever, Emerg. Infect. Dis
Ton, Gentile, Hsing, Ban, Cherkasov, Rapid Identification of Potential Inhibitors of SARS-CoV-2 Main Protease by Deep Docking of 1.3 Billion Compounds, Mol. Inform
Van Der Hoek, Pyrc, Jebbink, Vermeulen-Oost, Berkhout et al., Identification of a new human coronavirus, Nat. Med
Vaz, De Oliveira, Abouelella, Khater, The black seed, Nigella sativa (Ranunculaceae), for prevention and treatment of hypertension, Hypertens. Ser. "Recent Prog. Med. Plants
Venkatachallam, Pattekhan, Divakar, Kadimi, Chemical composition of Nigella sativa L. seed extracts obtained by supercritical carbon dioxide, J. Food Sci. Technol
Weiss, Navas-Martin, Coronavirus pathogenesis and the emerging pathogen severe acute respiratory syndrome coronavirus, Microbiol. Mol. Biol. Rev
Womack, Anderson, Tucci, Hamadain, Benghuzzi, Evaluation of bioflavonoids as potential chemotherapeutic agents, Biomed. Sci. Instrum
Wong, Liu, Liu, Zhou, Bi et al., MERS, SARS, and Ebola: the role of super-spreaders in infectious disease, Cell Host Microbe
Xu, Peng, Shi, Zhu, Mu et al., Nelfinavir was predicted to be a potential inhibitor of 2019-nCov main protease by an integrative approach combining homology modelling, molecular docking and binding free energy calculation, BioRxiv
Xu, Shi, Wang, Zhang, Huang et al., Pathological findings of COVID-19 associated with acute respiratory distress syndrome, Lancet Respir. Med
Yimer, Tuem, Karim, Ur-Rehman, Anwar, Nigella sativa L. (black cumin): a promising natural remedy for wide range of illnesses. Evidence-Based Complement, Altern. Med
Yoruk, Tatar, Keles, Cakir, Zaher et al., Observations on the biological effects of black cumin seed (Nigella sativa) and green tea (Camellia sinensis), Acta Otorhinolaryngol. Ital
Zaidi, Khan, Jabeen, Jahangir, A Review of Pharmacological & Clinical Researches on Shoneez (Nigella sativa Linn.)-A Unani Medicine, Indo Am. J. Pharm. Res
Zhang, Wu, Zhang, Deng, Peng, In silico screening of Chinese herbal medicines with the potential to directly inhibit 2019 novel coronavirus, J. Integr. Med
Zheng, SARS-CoV-2: an Emerging Coronavirus that Causes a Global Threat, Int. J. Biol. Sci
Zhu, Zhang, Wang, Li, Yang et al., A novel coronavirus from patients with pneumonia in China, N. Engl. J. Med
Zhu, Zhao, Xiang, Ye, Huang et al., Thymoquinone attenuates monocrotaline-induced pulmonary artery hypertension via inhibiting pulmonary arterial remodeling in rats, Int. J. Cardiol
